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Correspondence |

Dramatic Improvement of Facial Angiofibromas in Tuberous Sclerosis With Topical Rapamycin: Optimizing a Treatment Protocol

Cynthia M. C. DeKlotz, MD; Alicia E. Ogram, MD; Saurabh Singh, MD; Sridhar Dronavalli, MD; Jennifer L. MacGregor, MD
Arch Dermatol. 2011;147(9):1117-1118. doi:10.1001/archdermatol.2011.254.
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In a recent report on the use of topical rapamycin to treat facial angiofibromas, Haemel et al1 demonstrated the efficacy of rapamycin tablets mixed in petrolatum, 1%, ointment. Based on these findings and another report of topical rapamycin solution compounded with Eucerin (Eucerin, Hamburg, Germany),2 we proceeded with a similar approach in our patient with tuberous sclerosis complex (TSC).

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Figure. Facial angiofibromas before (A) and after (B) treatment with topical rapamycin, 1%.




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