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Correspondence |

Complete Response of Metastatic Malignant Hidradenocarcinoma to Capecitabine Treatment

Adam Lerner, MD; Angela Beckford, MD, MPH; Steve Ugent, MD; Lynne Goldberg, MD; Scharukh Jalisi, MD; Marie-France Demierre, MD
Arch Dermatol. 2011;147(8):998-999. doi:10.1001/archdermatol.2011.210.
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Malignant hidradenocarcinoma is a rare locally aggressive eccrine tumor with high metastatic potential.1 Few studies have reported effective therapy for this malignant neoplasm, and in none has a complete response been observed.2,3 We describe a patient with unresectable metastatic malignant hidradenocarcinoma who experienced a durable complete clinical and radiologic response after 3 months of oral capecitabine treatment.

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Figure. Histopathologic (A and B), clinical (C and D), and positron-emission tomographic computed tomography (PET-CT) (E and F) images. A, Low-power view of a specimen from a large, deeply invasive tumor with an area of necrosis shown (arrow) and clear cell change (hematoxylin-eosin, original magnification ×10). B, High-power view reveals mitotically active (arrow), atypical epithelial cells with focal clear cytoplasm (arrowhead) (hematoxylin-eosin, original magnification ×40). C, At presentation, multiple scalp nodules were present on the right side of the face. D, Following capecitabine treatment, complete resolution of all facial tumors was observed. E, At presentation, a PET-CT scan demonstrated metastatic disease with intensively fluorodeoxyglucose-avid areas in the scalp, parotid gland, and cervical lymph nodes. F, A repeated PET-CT scan following 3 cycles of capecitabine therapy revealed no evidence of residual activity in the scalp, parotid gland, or neck.




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