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Correspondence |

Keratitis-Ichthyosis-Deafness Syndrome: Response to Alitretinoin and Review of Literature

Siegfried Werchau, MD; Ferdinand Toberer, MD; Alexander Enk, MD; Peter Helmbold, MD
Arch Dermatol. 2011;147(8):993-995. doi:10.1001/archdermatol.2011.216.
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Author Affiliations: Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Correspondence: Dr Werchau, Department of Dermatology, University of Heidelberg, Vo ßstra ße 2, D-69115 Heidelberg, Germany (siegfried.werchau@med.uni-heidelberg.de).

Financial Disclosure: None reported.

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Figure 1. Clinical images of the leg. A, At the primary visit before treatment with alitretinoin, the skin appeared ichthyotic with a reddish hue, and hyperkeratotic plaques were present, especially on the distal extremities. B, A significant improvement in the skin symptoms was detectable after 5.5 months of alitretinoin treatment.

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Figure 2. Clinical images of the face. A, At the primary visit before treatment with alitretinoin, infiltrated erythema was present, with brownish hyperkeratotic areas around the eyelids. B, The skin alterations were significantly reduced after 5.5 months of therapy with alitretinoin.

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