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Correspondence |

Abscopal Effect in a Patient With Metastatic Merkel Cell Carcinoma Following Radiation Therapy: Potential Role of Induced Antitumor Immunity

Shane E. Cotter, MD, PhD; Gavin P. Dunn, MD, PhD; Kristina M. Collins, MD; Debjani Sahni, MD; Katherine A. Zukotynski, MD; Jorgen L. Hansen, MSc; Desmond A. O ’Farrell, MSc; Andrea K. Ng, MD, MPH; Phillip M. Devlin, MD; Linda C. Wang, MD, JD
Arch Dermatol. 2011;147(7):870-872. doi:10.1001/archdermatol.2011.176.
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Correspondence: Dr Wang, Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115 (lcwang@partners.org).

Financial Disclosure: Dr Devlin is a compensated member of the Nucletron scientific advisory board. Dr Wang is a compensated member of the ImmunoGen scientific advisory board.

Previous Presentation: This article was presented at the 2010 Society for Investigative Dermatology Meeting; May 5-8, 2010; Atlanta, Georgia.

Additional Contributions: Elizabeth Martin, BA, and Jay Omobono, BHS, provided technical support.

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Figure 1. Clinical Resolution. A, Right lower extremity cutaneous metastases are outlined in green. B, An untreated distant metastasis on the right ankle (circle) resolved after brachytherapy to lesions on the upper half of the right lower leg.

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Figure 2. Positron emission tomography (PET)/computed tomography (CT) resolution. A and B, From left to right, maximum intensity PET projection, axial PET, axial CT, and axial fused PET/CT images. Arrows point to the untreated right ankle metastasis before (A) and after (B) brachytherapy to metastases on the proximal half of the right lower leg. F indicates the imaging perspective: from the foot toward the head.




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