In this article, Zalaudek and colleagues present a global approach to the examination of benign and malignant pigmented nevi using dermoscopy. They review more than 118 publications and summarize the findings, with attention to dermoscopic criteria and patient-related factors. They provide dermoscopic images of typical benign nevi and illustrate how the appearance of these benign nevi changes with differing Fitzpatrick skin types. They used this method throughout their study, describing dermoscopic patterns and their variations with age, UV exposure, anatomical site, and pregnancy. Similarly, they also review the dermoscopic features of melanoma, with attention to eccentric hyperpigmentation, and compare these images with blue nevi and metastatic melanoma. They continually stress the importance of a thorough skin examination, including assessment of the type and distribution of nevi. With this extensive review, Zalaudek and colleagues offer a more comprehensive approach to dermoscopy whereby the interpretation of these images not only is based on pattern recognition but also is dependent on a wide range of patient-specific factors.