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Editorial |

DIRA, DITRA, and New Insights Into Pathways of Skin Inflammation:  What's in a Name?

Edward W. Cowen, MD, MHSc; Raphaela Goldbach-Mansky, MD, MHSc
Arch Dermatol. 2012;148(3):381-384. doi:10.1001/archdermatol.2011.3014.
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Figure. The pathogenesis of DIRA (deficiency of the interleukin 1 [IL-1] receptor [IL-1R] antagonist) and DITRA (deficiency of the IL-36 receptor [IL-36R] antagonist). Loss of the IL-1R antagonist leads to unopposed proinflammatory signaling by IL-1 α and IL-1 β in patients with DIRA. In DITRA, loss of the IL-36R antagonist results in analogous unchecked signaling by IL-36 α, IL-36 β, and IL-36 γ at the IL-36R (right panel). Patients with DIRA from Puerto Rico harbor a genomic deletion in both the IL-1R antagonist (left panel) and IL-36R antagonist (center panel). Because the IL-36 proinflammatory signaling isoforms are also deleted, a functional consequence of loss of the IL-36R antagonist in Puerto Rican patients with DIRA is unlikely.




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