0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
The Cutting Edge: Challenges in Medical and Surgical Therapies |

Treatment of Acquired Perforating Dermatosis With Cantharidin

Jessica Wong, BMedSci; Robert Phelps, MD; Jacob Levitt, MD
Arch Dermatol. 2012;148(2):160-162. doi:10.1001/archdermatol.2011.350.
Text Size: A A A
Published online

Extract

Many treatments have been proposed for acquired perforating dermatosis (APD), with varying success. In general, treatment is unsatisfactory and definitive resolution of existing lesions is difficult to achieve.

Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia (Ms Wong); and Departments of Pathology (Dr Phelps) and Dermatology (Dr Levitt), The Mount Sinai Medical Center, New York, New YorkCorrespondence: Jacob Levitt, MD, Department of Dermatology, The Mount Sinai School of Medicine Center, 5 E 98th St, Fifth Floor, PO Box 1048, New York, NY 10023 (jacoblevittmd@gmail.com).

Accepted for Publication: August 11, 2011.

Author Contributions: All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Levitt. Acquisition of data: Wong, Phelps, and Levitt. Analysis and interpretation of data: Wong, Phelps, and Levitt. Drafting of the manuscript: Wong, Phelps, and Levitt. Critical revision of the manuscript for important intellectual content: Wong, Phelps, and Levitt. Administrative, technical, or material support: Wong, Phelps, and Levitt. Study supervision: Levitt.

Financial Disclosure: None reported.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Graphic Jump Location

Figure 1. A, Acquired perforating dermatosis of the leg before treatment —note lichenified, hyperpigmented papules with central keratotic core. B, Acquired perforating dermatosis of the leg 7 days after cantharidin application, before debridement —note vesicle formation at the site of cantharidin application. Inset: Close-up of a debrided papule after cantharidin treatment; the hyperkeratotic core remains attached to the blister roof. C, Acquired perforating dermatosis of the leg 2 months after treatment and debridement; the lichenified papules and hyperkeratotic cores are no longer present, and the leg is smooth. D, Acquired perforating dermatosis of the leg 5 months after treatment. Treated lesions are smooth; however, a few new lesions have formed.

Place holder to copy figure label and caption
Graphic Jump Location

Figure 2. A, The epidermis shows an invagination filled with a large column of orthokeratotic and parakeratotic keratin. The adjacent dermis shows focal fibrosis and a mixed neutrophilic and mononuclear infiltrate (hematoxylin-eosin; original magnification ×10). B, A subepidermal bulla is shown with detachment of the epidermis, the dermis, and foci of dyshesion and necrosis (hematoxylin-eosin; original magnification ×10).

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

400 Views
4 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();