Accepted for Publication: March 22, 2011.
Published Online: May 16, 2011. doi:10.1001/archdermatol.2011.124
Author Contributions: Drs Pho, Smith, Bale, Konecki, Eliason, and Leachman had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Smith, McLean, Cohen, and Leachman. Acquisition of data: Pho, Konecki, Bale, and Eliason, and Leachman. Analysis and interpretation of data: Smith, Konecki, Bale, McLean, and Leachman. Drafting of the manuscript: Pho, Smith, and Leachman. Critical revision of the manuscript for important intellectual content: Pho, Smith, Bale, and Leachman. Statistical analysis: Leachman. Obtained funding: Leachman. Administrative, technical, and material support: Pho, Konecki, Bale, and Leachman. Study supervision: Pho and Leachman.
Financial Disclosure: Drs Konecki and Bale are employed by GeneDx and performed the mutational analyses.
Funding/Support: This study was supported by grants to Drs Pho and Leachman from the Pachyonychia Congenita (PC) Project (Salt Lake City, Utah; www.pachyonychia.org) and the Huntsman Cancer Foundation, and a grant to Dr Leachman from the Tom C. Mathews Jr Familial Melanoma Research Clinic. Dr Smith received funding from the the PC Project to perform the initial mutation analysis.
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We are grateful for the generous support, collegiality, and useful suggestions from members of PC Project, as well as the IPCC. Most of all, we would like to thank the patients with PC who have offered their unwavering support.