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Autologous Noncultured Melanocyte-Keratinocyte Transplantation Procedure in an African American Man With Postburn Leukoderma

Marsha D. Henderson, MD; Richard H. Huggins, MD; Sanjeev V. Mulekar, MD; David Ozog, MD; Henry W. Lim, MD; Iltefat H. Hamzavi, MD
Arch Dermatol. 2011;147(9):1025-1028. doi:10.1001/archdermatol.2011.238.
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Postburn leukoderma can cause significant distress for patients. Unfortunately, there are limited options for the treatment of postburn leukoderma.

Department of Dermatology, Multicultural Dermatology Center, Henry Ford Hospital, Detroit, Michigan (Drs Henderson, Huggins, Mulekar, Ozog, Lim, and Hamzavi); and National Center for Vitiligo and Psoriasis, Riyadh, Saudi Arabia (Dr Mulekar)Correspondence: Dr Hamzavi, Department of Dermatology, Henry Ford Hospital, 3031 W Grand Blvd, Ste 800, Detroit, MI 48202 (Ihamzav1@hfhs.org).

Accepted for Publication: April 16, 2011.

Author Contributions: All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Mulekar, Ozog, Lim, and Hamzavi. Acquisition of data: Henderson, and Huggins. Analysis and interpretation of data: Henderson and Hamzavi. Drafting of the manuscript: Henderson. Critical revision of the manuscript for important intellectual content: Huggins, Mulekar, Ozog, Lim, and Hamzavi. Obtained funding: Lim and Hamzavi. Administrative, technical, and material support: Henderson, Huggins, and Ozog. Study supervision: Mulekar, Ozog, Lim, and Hamzavi.

Financial Disclosure: Dr Lim serves as a consultant for La Roche-Posay/L ’Oreal, Orfagen, and Dow Pharmaceutical Sciences. The Henry Ford Hospital Department of Dermatology has received a research grant on photobiology from Johnson & Johnson. Dr Hamzavi serves as a consultant for Kythera and has worked as an investigator with Abbott, Johnson & Johnson, Centocor, Dow Pharm, Cipher, and Pfizer.

Funding/Support: This study was supported in part by the C. S. Livingood Education Fund and the Shahani Foundation.

Role of the Sponsors: The sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of data; or in the preparation, review, or approval of the manuscript.

Additional Contributions: Virginia Novak, RN, and Coleen Owens, RN, provided invaluable assistance.

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Figure 1. Our patient before (A) and after (B) autologous melanocyte-keratinocyte transplantation. A, Depigmented patches and macules involving the forehead and right cheek. B, Substantial repigmentation observed 6 months after the procedure.

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Figure 2. Right cheek area before (A) and after (B) autologous melanocyte-keratinocyte transplantation. A, Depigmented patches and macules. B, Substantial repigmentation observed 6 months after the procedure.

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