Reflectance confocal microscopy provides in vivo imaging of the epidermis and superficial dermis at cellular level resolution and can be used to detect cutaneous fungal1,2 and parasitic infestations.3 Reflectance confocal microscopy of an erythematous annular scaly patch on the abdomen reveals branching fungal hyphae (Figure 1, arrows), diagnostic of tinea corporis. A linear burrow on the wrist of a pruritic patient demonstrates Sarcoptes scabiei eggs with developing mites (Figure 2, wide arrow) and feces (Figure 2, narrow arrows). Characteristic features of Demodex folliculorum, which can be seen moving in a video that is available online here, are also shown in Figure 3: 8 legs (4 of which are indicated by narrow arrows) and an elongated body (wide arrow). Figure 4 reveals the native state of Demodex, with tails (arrows) protruding from a hair follicle (F). In vivo visualization of cutaneous organisms with reflectance confocal microscopy at the bedside provides an alternative to scrapings, microscopy, cultures, and biopsies.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Dermatology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 8
Customize your page view by dragging & repositioning the boxes below.
Reflectance Confocal Microscopy of Demodex folliculorum
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.