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Editorial |

Prevalence and Etiology of Central Centrifugal Cicatricial Alopecia

Valerie D. Callender, MD; Oge Onwudiwe, MD
Arch Dermatol. 2011;147(8):972-974. doi:10.1001/archdermatol.2011.205.
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Central centrifugal cicatricial alopecia (CCCA) is an inflammatory form of hair loss seen more commonly in women of African descent. It has been referred to as “hot comb alopecia, ”1 chemically induced scarring alopecia,2 and follicular degeneration syndrome,3 but the term CCCA was later coined by the North American Hair Research Society (NAHRS).4 This form of primary scarring alopecia occurs mainly on the vertex of the scalp, spreads peripherally, and produces permanent destruction of the pilosebaceous unit. Treatment is focused on halting the progression of disease and typically consists of topical and intralesional corticosteroid therapy and antibiotics such as doxycycline.5 In stable disease, hair transplantation in some cases has shown promise, although graft survival is low, and regrowth of the transplanted hair is slow.6,7 To our knowledge, there currently are no evidence-based published studies on therapeutic outcome in patients with CCCA, and further investigation is definitely needed.

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